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KMID : 0374019830060020057
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Ewha Medical Journal
1983 Volume.6 No. 2 p.57 ~ p.64
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The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes-Schmidiana Var Viridis-Pretreated Rats Liver Microsomes
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Abstract
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After rats were treated with CCl4, phenobarbital and artemisia messes-schmidiana var viridis ( artemisia), hepatic microsomal cytochrome P450, cytochrome bs and lipid peroxidation were investigated. When vitamin A, C and E were added incubation medium in each group respectively, lipid peroxidation was observed.
The results were as follows,
1) When administrated with CC14 in rats,- the contents of total microsomal cytochrome P - 450 and cytochrome bs were decreased by 58 % and 36 %, respectively. And lipid peroxidation was decreased by 6%.
2) When administrated with phenobarbital and artemisia. in rats respectively, the contents of total microsomal cytochrome P450 and cytochrome b5 were increased by 25 to 135 %. And lipid peroxidation was increased by 30 to 57 %.
3) When administrated with CC14 and phenobarbital or artemisia. in rats, the contents of, total microsomal cytochrome P450 and cytochrome b5 were increased by 8 to 35%. And lipid. peroxidation was increased by 4 to 1 a %.
4) When vitamin A, C and E incubated in each group in vitro. lipid peroxidation were decreased by 3 to 87%. And the higher concentrations of vitamin
A C and E were, the more lipid peroxidation was decreased.
,pct
These results indicate that vitamin antioxidants can prevent lipid peroxidation in `CC141 phenobarbital, CC14 with phenobarbital, artemisia. and CC14 with artemisia.- pretreated rat liver microsomes.
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